Change in GERD-Q questionnaire score, lower esophageal sphincter function by high resolution esophageal manometry, number of different types of gastroesophageal refluxes, and acid exposure time were assessed before and after patient diet modification increased intake of dietary fiber. Data were analyzed using non-parametric statistics. Our study is the first prospective trial demonstrating that increasing the amount of dietary fiber consumed results in an increase of minimal esophageal resting pressure and a decrease of the number of gastroesophageal refluxes and frequency of heartburn per week in patients with non-erosive GERD.
Diet modification with additional psyllium 5. Our results are consistent with epidemiological studies that found an inverse correlation between the amount of dietary fibers consumed and symptoms of GERD. We demonstrated that diet modification with an addition of These findings are promising and suggest that nutritional interventions may be effective in GERD management.
Get Rid of Heartburn and GERD Forever in Three Simple Steps | Chris Kresser
Well-planned trials are needed to examine further novel potential mechanisms of nutritional support for patients with esophageal disorders. Moreover, multicenter, placebo-controlled, dose-escalating trials are necessary to confirm our results, to establish the dose necessary to reach the optimal effect on esophageal motility and NERD symptoms, and to evaluate the effect of different types of dietary fibers. Authors acknowledge Dr. Manuscript source: Unsolicited manuscript.
Specialty type: Gastroenterology and hepatology. Country of origin: Russia. Peer-review report classification. Grade A Excellent : A. Grade B Very good : B, B. Clinical trial registration statement: This study registered at www. Informed consent statement: All participants signed the informed consent form. Peer-review started: March 27, First decision: April 11, Article in press: May 11, National Center for Biotechnology Information , U. Journal List World J Gastroenterol v. World J Gastroenterol. Published online Jun 7. Author information Article notes Copyright and License information Disclaimer.
Lifestyle plays just as important a role as medication
Author contributions: Morozov S, Isakov V, and Konovalova M contributed to the design and practical implementation of the study; Morozov S and Isakov V designed the research and wrote the paper; Morozov S and Konovalova M conducted research and analyzed data; all authors critically revised the manuscript; the authors had complete access to the data that support the publication; all authors have approved the final version of the manuscript. Published by Baishideng Publishing Group Inc.
All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. This article has been cited by other articles in PMC. Keywords: Gastroesophageal reflux disease, Psyllium, Gastroesophageal reflux, Lower esophageal sphincter relaxation, Esophageal motility, Dietary fiber, Heartburn, Non-erosive gastroesophageal reflux disease. Enrollment criteria Enrollment criteria were: willingness to participate in the study signed informed consent ; clinical diagnosis of NERD; dietary fiber deficiency confirmed by validated dietary questionnaire; and pathological gastroesophageal reflux by h esophageal pH-impedance.
Open in a separate window. Figure 1. Statistical analysis The obtained data were analyzed using standard software Statistica 10, StatSoft Inc. Table 1 Study population. BMI: Body mass index. Figure 2. Table 2 Results of the study. Research motivation Reflux disease symptoms are associated with low consumption of dietary fiber, according to epidemiological studies. Research objectives The main objective of the study was to evaluate the effect of increased dietary fiber consumption on the number of gastroesophageal refluxes, esophageal acidity, the lower esophageal sphincter pressure, and clinical manifestations of NERD in patients with low dietary fiber intake.
Research methods The study was conducted as a pilot single-center prospective trial with very strict inclusion criteria aimed to support the diagnosis and to exclude other reasons able to affect esophageal motility and NERD symptoms. Research results Our study is the first prospective trial demonstrating that increasing the amount of dietary fiber consumed results in an increase of minimal esophageal resting pressure and a decrease of the number of gastroesophageal refluxes and frequency of heartburn per week in patients with non-erosive GERD.
Research conclusions Our results are consistent with epidemiological studies that found an inverse correlation between the amount of dietary fibers consumed and symptoms of GERD. Research perspectives Well-planned trials are needed to examine further novel potential mechanisms of nutritional support for patients with esophageal disorders.
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